Pharmaceutical products such as vaccines, injectables, parenteral emulsions, and amorphous drugs are always evolving to provide the best performance for patient treatment. Dispersibility, shelf-life, crystallization, and inject-ability are key parameters that need to be controlled during product development and quality control.
Destabilization of colloidal system and dispersion are some of the major difficulties when talking about drug efficiency and targeting. Stability tests are critical when developing these types of formulas. Precisely determining particle size and particle size kinetics are essential parameters that need to be considered.
Turbiscan is a unique solution to determine particle size and particle migration, from nano to micro, in native sample. This is done without any dilution and in function of time, hence taking out of the equation the dilution bias and providing a global understanding of the colloidal and physical stability of the pharmaceutical product.
Predicting the real behavior of a formulation during its use can be challenging. This can be due to various parameters, from low viscosity and sample volume availability, to shear rates that may be limiting for traditional Rheometry.
Fluidicam provides the formulator with a way to characterize formulations at the right range of use regarding high shear rates and temperature. Using the microfluidic system, it takes only 3 min of analysis time and less than 4 mL sample volume.