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Pharmaceutical Dispersions: A Jedi’s Guide to Shelf-Life and Redispersion Properties

In a galaxy far, far away, innovation is the key to success for pharmaceutical companies to overcome challenges, present and future. The force has been strong with recent breakthroughs in drug and vaccine development, such as mRNA vaccines and protein therapeutics. However, with the rise of carriers like colloidal systems, Lipid Nano Particles, and liposomes, new challenges have emerged, particularly in the areas of encapsulation and targeting.

Online Particle Sizing for Raw Materials and Process Screening

Not well defined and most of the time unknown, the dispersibility of a formulation is essential to ensure its required end-use properties. The dispersion’s final quality mostly results from the de-agglomeration/emulsification process occurring in the initial dispersion state. Therefore, formulation scientists must first well disperse particles with the desired particle size and then make sure the product is stable over time.

Shelf-Life Prediction by Turbiscan

Dispersions and formulations are mixtures of non-miscible phases and are willing to separate. Avoiding phase separation is essential to keep end-use properties and a nice visual aspect over days, weeks, months, and sometimes years.

The determination of the Shelf-Life mostly relies on visual observation and is sometimes combined with high-temperature storage to accelerate the destabilization process.

Plant Protein Integration Into Food Products

Plant-based protein use has been expanding over the past years and offers numerous advantages: sustainable origins, vegan alternatives, cost-effective and health benefits. However, these proteins do not have the same performances compared to conventional emulsifiers and with the increasing offer, selecting the right protein can represent a bottleneck in new product and process development. Furthermore, Plant-protein performances highly vary in function of its origins (pea, soybean, sweet potato, chickpea…), purification process, and eventual chemical functionalization.

Optimizing Particle Stability by the Hansen Approach

To achieve stable dispersion and desired particle size, one of the very first and fundamental steps is solvent selection. Solvent plays a major role in particle dispersibility and strongly impacts the final particle size and particle stability.

Stability of Trendy Food Products

With the rise of trendy food and beverages, come a host of challenges to solve. Join us for this webinar to discover how Turbiscan technology can help you better understand and evaluate your physical stability challenges (sedimentation, clarification, creaming, ring formation), size variation, and shelf life.

Dispersibility of Food Ingredients

Dispersibility, usually associated with “particle dispersibility”, is one of the key parameters for better, faster, stronger, cost-effective, greener formulations and is the foundation stone of formulation and dispersed systems.

Dispersibility & Stability – a new tool for Formulators

Dispersibility, usually associated with “particle dispersibility”, is one of the key parameters for better, faster, stronger, cost-effective, greener formulations and is the foundation stone of the formulation and dispersed system.

Introduction to ISO/TS 21357 for mean particle sizing by SMLS

One of the issues in modern chemicals, pharma, and food industries is to deliver safe and reliable products. The stability and performance of many of such products depend on constituent particle dispersion state. Usual analytical techniques often use dilution and other dispersion preparations methods to evaluate particle size, size distribution, and other parameters.

Polymers as Stabilizers: What is the Impact on Stability?

When used at the right concentration, polymers have a positive impact on shelf life. However, at higher concentration, it may not only be more costly but will also lead to undesired and unexpected destabilizations (flocculation by depletion, particle sedimentation by tunneling, network compression…).

Optimizing Vaccine Efficiency and Dosage

Vaccine and vaccine technologies have been one of the major scopes of interest of the past months. To face current sanitary emergency, scientists have developed safe and stable vaccines at a speed never seen previously. To shorten the development time and at the same time ensure efficiency and safe vaccine, vaccine development and characterization are essential. Our next webinar will focus on How to Assess and optimize vaccine efficiency and dosage via fast, rapid, and objective measurement of the agglomeration state.

Turbiscan Applications: Fuel & Oil Formulation Analysis for Oil & Gas Industry

This presentation will review the Turbiscan SMLS technology and how it can be used to analyze fuel blends, lubricants, and other essential fluids in the oil and gas industry. In addition to ASTM D7061 which utilizes a separability number to measure of asphaltene stability using the Turbiscan, we will review the recent IMO 2020 regulations and the importance of adjusting heavy bunker fuels to meet the 0.5% sulfur standard by blending and other methods

Turbiscan Applications: Green Formulations Development and Stability

The presentation will review the Turbiscan SMLS technology and how it can be applied to create more sustainable formulations by replacing high carbon footprint ingredients that may be harmful to human and environmental health.

Particle Size Analysis with Turbiscan SMLS Technology

Turbiscan technology allows measuring particle size in your formulations without the need to dilute the samples. Advantages and applications will be presented in real case studies. The presentation will cover definitions and challenges faced by formulators.

Turbiscan Applications: Dispersibility, Stability & Redispersion Testing (Session2)

The presentation will cover definitions and challenges faced by formulators. We will explain how the SMLS technology can be used to reduce the development time of new formulations, optimize scale-up processes, or analyze the shelf life of finished products.

Turbiscan Applications: Stability & Shelf Life of Personal Care Formulations

During this webinar we will be presenting Turbiscan technology and will in-depth explain the advantages and application examples of stability analysis done using this SMLS technology. You will be able to understand the benefits of quantifying stability with a single number.

Turbiscan Applications: Stability of Metalworking Fluids

During this webinar we will be presenting Turbiscan technology and will in-depth explain the advantages and application examples of stability analysis done using this SMLS technology. You will be able to understand the benefits of quantifying stability with a single number.

Turbiscan Stability Index (TSI) and the TSI scale

During this webinar we will be presenting Turbiscan technology and we will in depth explain the Turbiscan Stability Index – the TSI, with all advantages and application examples. You will be able to understand the benefits of quantifying stability with a single number. We will explain how the TSI is calculated and how to understand its value.

Nanoparticles – Fate and Toxicity

Formulaction presented a study on the preparation of nanoparticle dispersion in cell culture media and its impact on stability/dosimetry prior to toxicological studies. It shows the “best practice” and guidelines for the preparation of the stock solution.

Vaccine Characterization

Enhanced immunogenicity by controlling stability and redispersion properties During this webinar, we will focus on the recently published method to study the redispersion capabilities of vaccines.

Turbiscan: The Reference Measurement for Analyzing the Stability of Your Dispersions

Turbiscan LAB allows rapid and ultra-precise identification of destabilization mechanisms (creaming, sedimentation, flocculation, coalescence, etc.). This solution has been used for 25 years in R&D and quality control laboratories for the development and routine control of liquid dispersions from raw materials to finished products.

Dispersion Stability in the Food Industry

Whether searching for new product, replacing ingredients or optimizing a formulation process, Formulaction provides a full range of instruments allowing to characterize food dispersions (emulsions, suspensions, foams…) in terms of quality (appearance and short term stability) and study storage conditions (long term stability, re-dispersing).

Stability of Pharmaceutical Dispersions

Whether searching for new product, replacing ingredients or optimizing a formulation process, Formulaction provides a full range of instruments allowing to characterize pharmaceutical dispersions in terms of quality (appearance and short term stability) and study storage conditions (long term stability, re-dispersing).

4 Steps to a Good Formulation with Turbiscan

We will be presenting Turbiscan technology and we will show how it helps improving formulation development and production along the whole life cycle. You will be able to understand the benefits of quantifying the phenomena and learn about the applications of Turbiscan technology on real life applications in material characterization.

Comprehensive Stability Analysis of Concentrated Emulsions and Dispersions

Turbiscan technology offers sensitive methods for dispersion state analysis to monitor and quantify occurring destabilization phenomena. From identification of occurring evolution, sedimentation/creaming kinetics calculations, phase thickness determination, aggregation or coalescence monitoring, particle size evolution to shelf life prediction, particle size characterization.